Pulmonary hypertension, according to Wikipedia, is an
increase of blood pressure in the pulmonary artery, pulmonary vein, or
pulmonary capillaries, together known as the lung vasculature. Patients with
this would have shortness of breath, dizziness, fainting, leg swelling and
other symptoms. It can be a severe disease with a markedly decreased exercise
tolerance and heart failure. According to historical record, it was first
discovered in 1891. Risk factors of pulmonary hypertension generally include
family history, congenital heart defects, cocaine use and chronic lung disease.
Studies for the cure of pulmonary hypertension are always on
the go, however, current therapies don’t cure the underlying disorder and the
long-term prognosis is poor, even with treatment. According to previous study,
reduced function of the protein angiotension converting enzyme 2 (ACE2) is
associated with pulmonary hypertension, heart failure and other disorders. And
replenishing ACE2 has been proved effective to prevent pulmonary hypertension
in animal studies before.
Based on the precious study evidence, in a recent study, by
employing transplastomic technology, scientists inserted new genes into the DNA
of chloroplasts, and by inserting genes coding for ACE2, the scientists have
created plants with large quantities of ACE2 in their leaves. After that, they
fed those frozen powdered leaves to some certain rats with drug-induced pulmonary
hypertension for four week. Finally, they found that the pulmonary blood
pressure decreased and function of the right side of the heart was also
This study, to some extent, may provide a low-cost and innovative
method for the treatment of pulmonary hypertension. But further study about it
is still in need.
This is written by Caroline from Creative BioMart, which is a world
leading Biotech Company.