Model studies related to vanadium biochemistry: recent advances and perspectives
Enrique J. Baran
de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias
Exactas, Universidad Nacional de La Plata, C. Correo 962, 1900-La
An open access article from J. Braz. Chem. Soc. vol.14 no.6 São Paulo Nov./Dec. 2003.
evidence on the need of the higher forms of life for vanadium has
accumulated during recent years. Model studies have become a very
important tool to attain a better understanding of different aspects of
the biochemistry of this bioelement. In this account we present the
results of our own studies, as well as those of other research groups,
on models related to different aspects of its metabolism and
detoxification and to vanadium dependent haloperoxidases. Additional
information about the interaction of the biologically relevant
oxovanadium(IV) cation with important bioligands, such as nucleotides,
carbohydrates, phosphates and related systems are also presented.
Keywords: vanadium, model studies, metabolism, detoxification, haloperoxidases, biologically relevant ligands