ALBUQUERQUE, Sergio de, LOPES, Ruberval Armando, SALA, Miguel Angel et al.
Abstract : They were studied the alterations and the level of deterioration of the parotid gland in mice infected with the RAL strain Trypanosoma cruzi. They were used albino mice (Mus musculus) of both sexes, due to the existence of sexual dimorphism of the salivary glands, inoculated with 2 x 104 blood trypomastigotes of the RAL strain of T cruzi. The animals were sacrificed at the 12th day of infection, coinciding with the parasitemic peak, and the parotid gland was histologically processed and histopathologically and histometrically studied. The results allow verifying intense parasitism in the parotid gland with structural disorganization and widespread atrophy of acini and ducts, more marked in the females. Concluding, the RAL strain of T cruzi shows an atypical behavior in relation to other strains, provoking more clear modifications in the females, probably due to the hormonal alterations motivated by the T cruzi
Keywords: Trypanosoma cruzi; RAL strain; Mouse; Parotid; Histopathology; Morphometry.
Int. J. Morphol., June 2007, vol.25, no.2, p.265-275. Full text available in Spanish.