Recent studies show that the natural compound isolated from the magnolia tree has the ability to help heart from hypertrophy. And the remedy has been applied by the people in Asia for centuries with acknowledge among a wide area of people, which gave the scientists inspiration to study the substances with the will to make it beneficial to more people out of Asia. The result presented by the researches is surprisingly positive and proved that the wisdom of ancient people is of great power, as they knew the property of the substance without the help of advanced equipment.
Cardiac hypertrophy is usually caused by chronic blood pressure, and endanger the health of people by increasing the risk of heart failure and malignant arrhythmia. The natural compound extracted from the magnolia tree is honokiol, and it works in a way to increase the SIRT3 level and slow the growth of cardiac muscle cells. SIRT3, a kind of protein, can help delay aging, resist stress, and regulate metabolism, which is important in reducing the thickness of heart wall.
After the injection of honokiol into mice, the growth of cardiac cells was reduced, and heart wall pre-thickness was decreased, besides, the muscle cells’ ability of contracting is weakened. SIRT3 plays an important role in energy metabolism and in anti-acetylation, which prevents the function alteration of proteins. With no SIRT3, the cell’s function may be impaired. It’s also showed that honokiol, with functioning on SIRT3, can help mice to escape from a mature hypertrophy.
When the SIRT3 level was tested in the mice heart muscle cells, it was found that the honokiol is super effective, and a very small amount can make the level of SIRT3 doubled in a period of 24 hours. In addition, no appreciable toxicity was detected in the test.
To prove the honokiol’s property on SIRT3, researchers did another experiment on mice, in which the SIRT3 gene was absent, it was found that the natural compound didn’t affect anything at all and no changes happened to the mice in the test. This might prove that honokiol can only directly increase the level of SIRT3. The natural compound honokiol is quite promising in the treatment of heart diseases, though its function is in single form in accord with the present studies.
Now honokiol is put into pharmaceutical use as a herbal remedy in the market. Still, researchers are working on to find out if it’s still effective with oral use of the compound, as in the experiments done in the past, all mice were injected with honokiol, not by having it directly. If the answer is yes for this issue, it will be much more convenient for its application.
As honokiol has been proved very effective in the treatment of heart diseases in Asia, more researches will be done to probe more unknown matters about the natural compound to make it fully contribute to the heart diseases therapy.