As we all know, free radicals can cause damage, death and aging of cell, but scientists’ recent discovery just refutes this theory. Recently, researchers from University of Michigan have discovered a new protein. This protein can strongly fight against free radicals in the body, but the free radicals are a radical activator of this protein at the same time. The mutations of this kind of genes in the human body would induce rare neurodegenerative disease. The research of recombinant proteins just indicates the conclusion.
Head of the search and associate professor of cellular and molecular biology Xu Haoxing at University of Michigan said, "As material recycling center of the cell, lysosome can remove the necrotic cell fragments. When lysosome senses excessive free radicals in the cell, it will open the calcium channels of film surface and then start the expression of many genes and enhanced lysosomal scavenging capacity. The ultimate goal is to remove the damaged part of the cell.
Professor Xu said, "The role of free radicals in cells is very special. If there is a chemical substance that can directly start the open of ion channels. Then the effects of oxidative stress in aging diseases can be reduced, and the level of free radicals and cell damage will also decrease, thus finally realizing the possibility of anti-aging."
Then how the body identify whether free radicals are excess in cell? After using recombinant mouse proteins and recombinant rat proteins, he said, "Nature has wonderful ability in regulation. Lysosome itself has the ability to perceive the radical. MCOLN1 is sensor for ROS reactive oxygen species in lysosomes, and they can regulate autophagy of the cell."
The roe of free radicals in the human body is a double-edged sword: excessive levels can damage cells, while they can also ensure the body’s antioxidant capacity at an appropriate level. Therefore, to ensure the balance of free radicals can delay the body’s cells aging and enable lysosome to promptly clear harmful substances of the body. Eventually, we found that not every theory is established without any doubt. With the development of science and technology, we will go farther and farther to explore the unknown. Flarebio provides recombinant proteins such as recombinant of good quality.
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