Principles of Biochemistry With a Human Focus
PRINCIPLES OF BIOCHEMISTRY WITH A HUMAN FOCUS provides pre-med, junior, and senior science majors the most up-to-date coverage of biochemistry and a distinct focus on the topics most relevant to human health and medicine. Written by a chemist (Grisham) and a biologist (Garrett), the book presents biochemistry from a balanced perspective. PRINCIPLES OF BIOCHEMISTRY stresses the principles governing structure, function, and interactions of biological molecules.
Univ. of Virginia, Charlottesville. Textbook is provides the fundamental principles governing the structure, function, and interactions or biological molecules. Specifically discusses the molecular components of cells, protein dynamics, metabolism and its regulation, and information transfer. Features chapter exercises and summaries. Previous edition: c1998. –This text refers to the Hardcover edition.
About the Author(s)
Reginald H. Garrett was educated in the Baltimore city public schools and at the John Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has been at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. He is a former Fulbright Scholar, was a Visiting Scholar at the University of Cambridge on two sabbatical occasions, and served as Invited Professor at the University of Toulouse, France. He has taught biochemistry at the University of Virginia for 39 years. He is a member of the American Society for Biochemistry and Molecular Biology. Charles M. Grisham was born and raised in Minneapolis, Minnesota, and educated at Benilde High School. He received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he joined the faculty of the University of Virginia, where he is Professor of Chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. He is a Research Career Development Awardee of the National Institutes of Health, and in 1983 and 1984 he was a Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark. He held the Knapp Chair in Chemistry in 1999 at the University of San Diego. He has taught biochemistry and physical chemistry at the University of Virginia for 32 years. He is a member of the American Society for Biochemistry and Molecular Biology.
Well-written, not-so-hot layout, November 16, 2005
My university uses this book for the two-semester biochem sequence for BSc Chemistry/Biochemistry students. It’s a well-written book, overall — lots of information but not a very dense "scientific" read. The best part is the way the authors keep tying things back to reality … sidebars explain how the dynamics of protein folding affect Alzheimer’s disease, or what protease inhibition means for the development of HIV drugs.
The figures are aesthetically pleasing and really help to clarify descriptions in the text. The only problem is that the figures are usually a couple pages away from the text they refer to. For example, when describing the mechanism of chymotrypsin cleavage, it would make a lot more sense to put all the text on the left page and the mechanism/structures on the right page. Instead, the text is about three pages before the mechanism, meaning the reader has to keep flipping back and forth trying to understand what is going on. It’s like that in most if not all cases. Not a big deal, but it’s the sort of thing the layout editor should have realized when putting the book together. Maybe they’ll fix it in the fourth edition.
Regardless, this is a very good biochem book. I’d recommend it for an undergraduate student of chemistry or biochemistry.