Receptors: Models for Binding, Trafficking, and Signaling
Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes–from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.
About the Author(s)
Douglas A. Lauffenburger is at University of Illinois, Urbana. Jennifer Linderman is at University of Michigan, Ann Arbor.
A book for the modern biologist, April 22, 2004
This book will surely be thought of as the first structured presentation of principles of modern systems biology. This book introduces the application of Chemical Engineering to biologists and molecular biology and pharmacology of receptors to Chemical Engineers. The top-down picture of coupled processes is not only new to biologists but introduces a whole new way to look at biological problems. Especially the chapter which has cell migration explained introduces one to multi-dimensional thinking: cell mechanics, biochemistry, kinetic modeling and molecular biology all in the same problem. This may seem mystical to many. Would probably be read more by Engineers than biologists, who are yet to take the leap in thought to multi-dimensional science.This book would be remembered after many years to be a pioneer in the new science of systems biology, although it was written much before the Human Genome Project. Systems thinking and Chemical Engineering has been much beneficial in solving some very important biomedical problems like Drug Delivery(Robert Langer), Tumor Biology(Rakesh Jain) and Tissue Engineering(Robert Langer et.al.). Lauffenburger’s work would be counted among these shining lights when these methods and tools bear fruit sooner than later.(Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August 2002.Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology.