A non-motile coccobacillus gram-negative organism that emerged singly or in pairs associated with whooping cough in human.
Bordetella pertussis contains filamentous hemoagglutinin that is nutritionally fastidious which able to invade tissues and become pathogenic in humans. It is the bacterium responsible for whooping cough in human causing high mortality rate in infants. It also generates various substances with toxic activity like endotoxins and exotoxins.
Bordetella pertussis colonizes the cilia of mammalian respiratory epithelium which used several toxins to bind and destroy the epithelial cells. Its mode of infection is through utilizing hemoagglutinin that aids the bacteria in binding to the cilia surface then releasing pertussis toxin an exotoxin which able to enters the cell and activates the production of cAMP, finally it releases the tracheal cytotoxin causes the destruction of the cilia in the epithelial cells.
Bordetella pertussis has the ability to infect the function of host immune system which inhibits the G protein coupling resulted in phagocytes that converts too much ATP to cyclic AMP causing disturbances in cellular signaling mechanisms as well as preventing phagocytes from correctly responding to an infection.
Class: Beta Proteobacteria
Species: Bordetella pertussis
• Whooping cough