a genus of viruses in the family Bunyaviridae; a serologic group of the genus Bunyavirus; associated with cases of Bwamba fever in Uganda.
Origin: Bwamba, forest in Uganda where first isolated
Bwamba fever is caused by microscopic bacteria. Bwamba fever virus is from the genus Orthobunyavirus and belongs to the order bunyaviridae. It has a negative sense single stranded rna genome, and so is classified as a class v virus.
The disease is mainly spread by mosquitoes or by humans. Although bwamba fever is about as deadly as the common cold people should still be aware of it and the symptoms. Most of the time, Bwamba fever is mistaken for malaria, which is a deadly disease if left untreated.
bwamba virus (BWA) is a member of the Bunyamwera serogroup, bwamba virus antigenic group, in the genus bunyavirus, family bunyaviridae.1-3 bwamba virus is an arthropod borne virus transmitted by mosquitoes,
The structure of a Bwamba fever virus is segmented RNA’s are surrounded by nucleocapsid proteins that form a complex ribonucleoprotein, which associates with rna dependent rna polymerase. The complex is surrounded by a lipid layer, into which the nuclear complex interacts. Finally the particle is membrane bound, spherical, and in total is approximately 100nm in diameter.
Once inside a host cell cytoplasm, the genomic RNA’s are transcribed into mrna by the associated rna polymerase. From these transcripts, the host machinery is used for translation into viral proteins. The s segment is slightly different from the rest as it is ambisense, meaning genes run in both the positive and negative directions. To enable correct translation of the proteins, a second round of transcription has to occur. To replicate the genome, transcription occurs to produce a replicative intermediate, which is then itself transcribed into new rna genomes, with the aid of the rna polymerases produced from the gene Expression.
Bwamba fever virus is transmitted from vertebrate to vertebrate through a mosquito vector, Anopheles funestus, and causes Bwamba fever. The fever is often mistaken for malaria, and was only identified in the later 1990’s and is believed to be endemic in east Africa, especially kenya, tanzania and Uganda, where the virus was first identified by the Uganda virus research institute. there is no specific treatment for the virus, as it causes only a mild fever.