Member of caspase family that is significant in apoptosis and cytokine processing.
Caspase 9 is mapped to chromosome 1p36.3-p36.1 that contains a genomic coordinates of 1:15,818,768 – 15,851,284 and has a crystal structures with BIR3 in an inhibitory domain of XIAP at 2.4 angstrom that consists of 9 exons with a span of approximately 35kb of genomic DNA in a sequence of QACGG which possesses a longer N-terminal pro-domain.
Caspase 9 is present in the ovary, testis and heart that express high level of mRNs due to alternative splicing and able to cleave caspase 3. Its activity is regulated by phosphorylation that inhibits proteolytic processing which increase dramatically upon association with the apoptosome complex. Inhibition of caspase 9 would render opportunity to treat patients suffering from neurological diseases like brain injury caused by hypoxia, stroke and neurodegenerative diseases.
Caspase 9 leads the activation when cell receive apoptotic stimuli wherein mitochondria releases cytochrome c which then binds to Apaf-, a mammalian Ced-4 homologue together with dATP that resulted in complex recruits, such activity cleaves downstream caspases such as Caspase-3, 6 and 7 initiating the cascade thus, caspase 9 is vital for apoptosis during normal development of the central nervous system.
Gene name: CASP9
Protein name: Caspase-9
• Apoptotic protease Mch-6
• Apoptotic protease-activating factor 3
• Proteolysis Map