Dictionary > Ceruloplasmin

Ceruloplasmin

Definition
noun, plural: ceruloplasmins
A serum glycoprotein that is apparently involved in copper detoxification and storage; a ferroxidase
Supplement
Ceruloplasmin is a glycoprotein that contains six atoms of copper in its structure. It occurs in serum together with other biomolecules. In particular, it is a blue copper-containing ferroxidase with a molecular weight of about 135 kD. Apparently, it is involved in copper detoxification and storage. Possibly, it is also involved in the mopping up of excess oxygen radicals or superoxide anions. It may have also been playing a role in iron metabolism. It might have been assisting transferrin, another glycoprotein that is primarily involved in the transport of iron ions. Transferrin transports iron in the ferric state (Fe3+) to various tissues and organs via the bloodstream. Ceruloplasmin, possibly, oxidizes ferrous iron (Fe2+) to ferric iron (Fe3+), the iron ion of which transferrin can bind to.
In humans, ceruloplasmin is encoded by the CP gene. It is synthesized in the liver. Deficiency of ceruloplasmin is associated with Wilson disease, Menkes disease, and aceruloplasminemia. Some of the possible causes of low ceruloplasmin levels are genetic dysfunction and malnutrition. Excess ceruloplasmin is observed in copper toxicity, zinc deficiency, lymphoma, rheumatoid arthritis, Alzheimer’s disease, etc.
Variant(s):

  • caeruloplasmin

Synonym(s):

  • ferroxidase
  • See also:


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