Dictionary > Chromosome 18

Chromosome 18

Definition
noun
In humans, the autosome that spans about 80 million base pairs, likely to contain about 200 to 300 genes, and with a submetacentric chromosome
Supplement
In humans, the chromosomes occur in pairs and a typical somatic cell would contain 23 pairs of chromosomes in the nucleus. Each of these pairs has a characteristic length and banding pattern. There are two types of chromosomes: autosomes and allosomes. There are also two sets: the first set comes from the mother and the second set, from the father. Using idiograms, each chromosome may be identified one from the other based on the relative size and the banding pattern.
Chromosome 18 is a submetacentric autosome. It spans almost 80 million base pairs (i.e. about 2.5 % of the total DNA). It is likely to contain about 200 to 300 genes. Some of the genes are CABYR (coding for calcium-binding tyrosine phosphorylation-regulated protein), ELAC1 (for elaC ribonuclease Z 1), TMEM241 (for transmembrane protein 241), and ZNF532 (for zinc finger protein 532).
Some of the diseases and disorders related to the genes on chromosome 18 include Niemann-Pick disease type C, porphyria, selective mutism, trisomy 18, tetrasomy 18p, and monosomy 18p.
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