Dictionary > Chromosome 8

Chromosome 8

Definition
noun
In humans, the chromosome that spans about 145 million base pairs, likely to contain about 700 to 800 genes, and is a submetacentric chromosome
Supplement
In humans, the chromosomes occur in pairs and a typical somatic cell would contain 23 pairs of chromosomes in the nucleus. Each of these pairs has a characteristic length and banding pattern. There are two types of chromosomes: autosomes and allosomes. There are also two sets: the first set comes from the mother and the second set, from the father. Using idiograms, each chromosome may be identified one from the other based on the relative size and the banding pattern.
Chromosome 8 is a submetacentric autosome. It spans almost 145 million base pairs (i.e. about 4.5 to 5 % of the total DNA). It is likely to have about 700 or less than 800 genes. It bears many genes involved in the development and the function of brain. It has a region that is prone to mutation or with a high mutation rate. It is also this region that shows how humans diverged significantly from the chimpanzees.
Some of the diseases and disorders related to the genes on chromosome 8 include Burkitt’s lymphoma, COACH syndrome, cleft lip and palate, and primary microcephaly.
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