Dictionary > Cos cell

Cos cell

Cos cell
(Science: cell culture) a cell line derived from the african green monkey and used for transfection and cloning. The cells are simian fibroblasts (cv 1 cells) transformed by sv40 that is deficient in the origin of replication region.
They express large t antigen constitutively and if transfected with a vector containing a normal sv40 origin have all the other early viral genes necessary to generate multiple copies of the vector and thus to give very high levels of expression.

Last updated on January 20th, 2021

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