Dictionary > Diltiazem


Ditiazem (chemical formula: C22H26N2O4S) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. Its pharmacological actions are as follows: antihypertensive agents, calcium channel blockers, cardiovascular agents, teratogens, vasodilator agents. It may also serve as a direct, potent negative chronotrope with only mild negative inotropic effect. It slows conduction in AV node and produces coronary vasodilation with less systemic vasodilation than verpamil. In medicine, it is used to control ventricular response with atrial fibrillation in doses of 0.25 mg/kg iv over 2 minutes. Administration may be repeated at 0.35 mg/kg after 15 minutes. Maintenance infusion is at 5 – 15 mg/hr. Potential complications are less hypotension than with verapamil since less vasodilation and myocardial depression, bradycardia, possible exacerbated AV block, and synergistic interaction with beta-blockers. It is relatively contraindicated with congestive heart failure. It should be noted that diltiazem can accelerate heart rate and decrease blood pressure, especially in patients with Wolff-Parkinson-White or wide-complex tachycardia. Synonym: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-

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