Dictionary > Exonuclease

Exonuclease

Definition
noun, plural:exonucleases
A nuclease that catalyzes the hydrolysis of phosphodiester bond, cleaving a single nucleotide from the end of a polynucleotide chain.
Supplement
The enzyme may occur as individual enzyme or as part of a larger enzyme complex. For instance, DNA polymerase I has 3′ to 5′ exonuclease activity which is used in editing and proofreading DNA for errors.
Word origin: Greek éxō (outside) + nuclease.
Compare: endonuclease

See also: proofreading


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