Dictionary > Factor VII

Factor VII

A blood clotting factor of the extrinsic pathway of the blood coagulation cascade that is activated into factor VIIa when bound to tissue factor
Coagulation, the process of clot formation, involves platelet and blood clotting factors. In humans, the coagulation mechanism is comprised of two processes, i.e. the primary hemostasis and the secondary hemostasis. The latter entails two pathways: (1) intrinsic pathway (contact activation pathway) and (2) extrinsic pathway (tissue factor pathway). Both pathways lead to the formation of fibrin.
Factor VII is a blood clotting factor that is produced from the liver. The gene that codes it is on chromosome 13 (13q34). Its production is activated by the tissue factor. The tissue factor is an integral membrane glycoprotein encoded by the F3 gene. It is expressed on the cell surface when there is an injury in blood vessels. It is produced by sub-endothelial cells and cells (e.g. fibroblasts) that surround blood vessels. It is also expressed on the surface of endothelial cells and monocytes when they become exposed to inflammatory molecules (e.g. TNF-alpha). The tissue factor is involved in the initiation of thrombin formation. It has an affinity for the clotting factor VII. Exposed tissue factor due to injured blood vessel binds to factor VII. When bound, factor VII is activated into factor VIIa by proteases (e.g. thrombin). The complex formed stimulates the initiation of the coagulation protease cascades, particularly catalyzing the conversion of clotting factor X (Stuart factor) and clotting factor IX (Christmas factor) into active proteases, i.e. factor Xa and IXa, respectively.
Factor VII deficiency is the associated genetic disorder with this factor.
Also called:

  • (blood-) coagulation factor VII
  • proconvertin
  • clotting factor VII
  • convertin
  • cothromboplastin
  • serum accelerator
  • serum acceleratorglobulin
  • serum prothrombin conversion accelerator
  • activated blood coagulation factor VII

See also:

  • clotting factor
  • coagulation

    You will also like...

    Growth and Plant Hormones
    Growth and Plant Hormones

    Plants, like animals, produce hormones to regulate plant activities, including growth. They need these hormones to respo..

    Salmon jumping upstream in the river
    Lotic Communities & Animals

    A running water environment offers numerous microhabitats for many types of animals. Similar to plants, animals in lotic..

    Geological Periods
    Geological Periods

    Geological periods is a study guide that cites the different geological periods on Earth's timeline. Each has a brief ov..

    Population Regulation in an Ecosystem
    Population Regulation in an Ecosystem

    With regard to the population size of a species and what factors may affect them, two factors have been defined. They ar..

    Darwin's Finches - Natural Selection
    Darwin and Natural Selection

    This tutorial investigates the genetic diversity in more detail. It also delineates how certain alleles are favored over..

    Schematic diagram of DNA replication
    DNA Structure & DNA Replication

    DNA is a double helix structure comprised of nucleotides. A nucleotide, in turn, is made up of phosphate molecule, deoxy..