A glycoprotein involved as a local regulator of activin action in gonadal development and gametogenesis essential for normal reproduction.
Follistatin-like 3 gene is mapped on chromosome 19p13 that contains 5 exons span at about 7004bp which give rise to the main transcript of 2525bp consisting of 263 amino acids responsible for directing the protein to the secretory pathway. It has 2 follistatin domains typified by a conserved arrangement of 10 cysteine residues with two possible N-glycosylation sites on aspargines 73 and 215.
Follistatin-like 3 is abundantly expressed in placenta and testis but low or absent in the hematopoietic system that functions to bind activin A and with lower affinity to TGF beta family including activin B, myostatin and BMP2. It does not contain heparin binding structures thereby does not bind cell surface heparan-sulfate proteoglycans.
Follistatin-like 3 gene mutations implicated in malignant blood disorders, breast carcinoma, hepatocellular carcinoma, endometrial adenocarcinoma, pre-eclampsia and heart diseases that contributes to tumorigenesis by antagonizing growth limiting activin effects. It is elevated in heart failure in which expression correlated with markers of disease severity wherein protein is localized on myocytes and endothelium involved in signal transduction and transcription.
Gene name: FSTL3
Protein name: Follistatin-related protein 3
• Follistatin-like protein 3
• Follistatin-related gene protein
• Activin A