A member of peroxidase antioxidant enzyme family contributed in protecting cell surfaces, enzymes and extracellular fluid components from oxidative stress by catalyzing the reduction of hydrogen peroxide, organic hydroperoxide and lipid peroxides by means of reduced glutathione.
Glutathione peroxidase 2 gene mapped on chromosome 14q24.1 which happen to be an intronless that has deletion of single nucleotide in coding region and poly A tail at 3-prime untranslated region. It is a member of glutathione peroxidase antioxidant enzyme family that mainly expressed in the liver and intestinal epithelial cells where it partakes in the detoxification of dietary organic hydroperoxides.
Glutathione peroxidase 2 plays a role in protecting mammals from toxicity of ingested organic hydroperoxides like tert-butyl hydroperoxide, linoleic acid hydroperoxide and cumene hydroperoxide. It acts as a protective system against oxidative stress and is upregulated in an array of carcinomas that functions as an anti-inflammatory and anti-apoptotic molecules.
Glutathione peroxidase 2 encodes a selenium dependent glutathione peroxidase, an isoenzymes responsible for the majority of glutathione hydrogen peroxidase reducing activity in the epithelium of the gastrointestinal tract in which the locus contains selenocysteine residue encoded by UGA codon that usually signals translation termination.
Gene name: GPX2
Protein name: Glutathione peroxidase 2
• Gastrointestinal glutathione peroxidase
• Glutathione peroxidase-gastrointestinal
• Glutathione peroxidase-related protein 2
• Peroxidase enzyme