Dictionary > Immunoglobulin E

Immunoglobulin E

Definition
noun
An immunoglobulin (antibody) with ε-type of heavy chain, and in humans, is chiefly involved in type I hypersensitivity and in protecting against parasites such as helminths
Supplement
The plasma cell produces immunoglobulins (or antibodies) as an immune response to an antigen, i.e. non-self agent. An immunoglobulin (Ig) is a glycoprotein with a Y-shape. The basic structure of a monomeric unit of antibody consists of two identical heavy chains and two identical light chains. In each of these chains, there are variable and constant regions. The immunoglobulin heavy chain, in particular, is the large polypeptide subunit. It can be used to classify the various isotypes (or classes) of immunoglobulins. In humans and other mammals, the five classes are: (1) immunoglobulin A (IgA), (2) immunoglobulin D (IgD), (3) immunoglobulin E (IgE), (4) immunoglobulin G (IgG), and (5) immunoglobulin M (IgM).
The immunoglobulin E (IgE) has ε (epsilon)-type of immunoglobulin heavy chain (thus, the acronym E). The light chain of IgE may either be kappa (κ) or lambda (λ). Its molecular formula is ε2 κ2) or ε2λ2. In humans, IgEs are monomers. That means they have only one functional unit of antibody. IgEs are present in serum but only in very low amounts. They are produced and expressed on the surface of plasma cells.
IgEs are associated with type I hypersensitivity. They do so by attaching to mast cells and basophils via the latters’ IgE-specific Fc receptors (FcεRs). The binding may occur even before IgE interacts with allergens. When bound with allergen, this triggers the cells to release inflammatory mediators such as histamine. IgEs are also involved in protecting the body against parasites, especially helminths (e.g. nematodes) and protozoans (e.g. Plasmodium falciparum).
Abbreviation/Acronym:

  • IgE

See also:

  • B cell
  • immunoglobulin


    You will also like...

    running freshwater community
    Running Water Freshwater Community Factors

    This tutorial noted some of the physical and chemical factors that provide the framework of a running water community in..

    Still Water Animals
    Still Water Animals

    Animals living in aquatic habitats have diversified and evolved through time. They eventually occupy ecological niches a..

    Cell Respiration
    Cell Respiration

    Cell respiration is the process of creating ATP. It is "respiration" because it utilizes oxygen. Know the different stag..

    Gibberellins and Gibberellic Acid
    Gibberellins and Gibberellic Acid

    This tutorial describes the role of gibberellin family in plants. Find out the effects of gibberellin on plant growth an..

    Pollution in Freshwater Ecosystems
    Pollution in Freshwater Ecosystems

    There are many environmental factors that arise due to the usage of water in one way or another and for every action tha..

    A chart depicting Mendel's Law of Dominance
    Mendel’s Law & Mendelian Genetics

    One of Mendel’s law of inheritance is the “law of dominance”. Read this tutorial to know more about this form of i..