Dictionary > Integrin-binding sialoprotein

Integrin-binding sialoprotein

Definition
noun
A glycoprotein belongs to the integrin-binding family of phosphoprotein involved in bone mineralization.
Supplement
Integrin-binding sialoprotein gene mapped on chromosome 4q21.1 that contains 7 exons at approximately 70kD that undergoes posttranslational modifications which constitutes of 12% noncollagenous proteins in human bone synthesized by skeletal cell types, hypertrophic chondrocytes, osteoblasts, osteoclasts and osteocytes as such trophoblast is the only extraskeletal sites of its synthesis.
Integrin-binding sialoprotein is a major structural protein of bone matrix that binds to calcium and hydroxypatite via its acidic amino acid clusters and intercede cell attachment though an RGD sequence that recognizes the vitronectin receptor. It is extremely glycosylated and sulfated phosphoprotein that is present almost entirely in mineralized connective tissues.
Integrin-binding sialoprotein expressed in adult kidney mostly in nephron segments. It enhances osteogenic cell migration through basement membrane and collagen matrices by localizing MMP-2 on the cell surface through alpha/beta integrin. It is a member of SIBLING (small integrin-binding ligand N-linked glycoprotein) family that are recognized to construct non-collagenous extracellular matrices of calcified tissues arisen by duplication and subsequent divergent evolution of a single ancient gene thereby IBSP molecule might gradually intensified its functions related to calcification during its evolutionary process.
Gene name: IBSP
Protein name: Bone sialoprotein 2
Synonyms:
Bone sialoprotein II
BSP
BNSP
SP-II
BSP-II
Cell-binding sialoprotein
See also:
Glycoprotein
Bone


You will also like...

human respiratory system
Respiration

The human respiratory system is an efficient system of inspiring and expiring respiratory gases. This tutorial provides ..

Hominid
The Hominids

The hominid family diversified from the apes around 6 to 8 million years ago. Since then, the evolutionary path has prov..

Community Patterns

Learn about community patterns and the ecological factors influencing these patterns. Revisit some of the ecosystems you..

Freshwater aquatic plankton
Freshwater Communities & Plankton

Planktons are microscopic organisms that live suspended in aquatic habitats. There are two groups: the phytoplanktons an..

Muscle
Muscle

Muscle cells are specialized to generate force and movement. Learn about the different types of muscle tissues in this t..

Ecosystem Succession
Ecosystem Succession

If the balance of nature is left untouched, landscapes can change dramatically over time. A previous ecosystem is supers..