A key transcriptional regulator of type I interferon-dependent immune responses that is significant in innate immune response against DNA and RNA viruses.
Interferon regulatory factor 3 gene mapped on chromosome 19q13.33 that is present in inactive cytoplasmic form upon serine/threonine phosphorylation form complex located in carboxy terminus. It regulates the IFN-alpha and IFN-beta by binding to an interferon-stimulated response element in which it acts more potent activator in IFN-beta than IFN-alpha gene that both functions in early and late phase gene induction.
Interferon regulatory factor 3 induces a conformational change leading to its dimerization and nuclear localization and association of CREB binding protein that can activates type I IFN genes. It reveals to possess no intrinsic transcriptional activation potential that interacts with transcriptional coactivators binding protein but not with p300. Knockdown of endogenous Hsp90 by RNA intrusion attenuates IRF3 establishment and its target gene expression.
Interferon regulatory factor 3 mediates the suppressor RIG-I in hepatitis A virus to block the induction of beta interferon in which it is needed jointly with stimulator -1 for efficient apoptosis following virus infection showing similar mechanisms of antiviral cytokine induction and activation of the cell death response.
Gene name: IRF3
Protein name: Interferon regulatory factor 3
• Interferon regulatory protein
• Cell cycle