Dictionary > Lipoxin

Lipoxin

Definition
noun, plural: lipoxins
Any member from the subfamily of eicosanoids, with a chemical formula of C20H32O5, and involved in the regulation of inflammatory responses
Supplement
Eicosanoid is the generic term to refer to the compounds derived from arachidonic acid or other polyunsaturated fatty acids of 20-carbon length. Some of the prominent eicosanoids include (1) eoxins, (2) leukotrienes, (3) lipoxins, (4) prostacyclin, (5) prostaglandins, (6) resolvins, and (7) thromboxanes.
Lipoxins belong to a subfamily of eicosanoids that have a chemical formula of C20H32O5. They are produced by various cells. They regulate inflammation. There are two chemically identified lipoxins: lipoxin A4 (LXA4) and lipoxins B4 (LXB4). They were first observed to be produced by human neutrophils.
Pro-inflammatory arachidonic acid metabolites and certain cytokines (e.g. IFN-γand IL-1β) stimulate the biosynthesis of lipoxins. Lipoxins are derived from arachidonic acid, through the enzyme, 15-lipoxygenase.
Lipoxins may also be categorized as a subgroup of polyunsaturated fatty acid metabolites. In this regard, they belong to the specialized pro-resolving mediators (SPMs) characterized by being arachidonic acid metabolites having four double bonds and three hydroxyl residues. The SPMs are formed to stimulate cells and tissues that would reverse the actions of pro-inflammatory mediators so that the inflammatory response is dampened and reversed, and so that tissue repair will be initiated.
IUPAC name:

  • 5S,14R,15S-Trihydroxy-6E,8Z,10E,12E -eicosatetraenoic acid

Chemical formula:

  • C20H32O5
  • Abbreviation:

    • LX

    See also:

  • eicosanoid


    You will also like...

    Biological Energy
    ATP & ADP – Biological Energy

    ATP is the energy source that is typically used by an organism in its daily activities. The name is based on its structu..

    Carbohydrates, fats and proteins - dietary sources
    A Balanced Diet – Carbohydrates and Fat

    Apart from vitamins, the human body also requires high energy sources such as carbohydrates and fats. If you want an ove..

    Balanced Diet
    A Balanced Diet – Minerals and Proteins

    Proteins and minerals can be derived from various dietary sources. They are essential for the proper growth and developm..

    Chemical effects on plant growth and development
    Effect of Chemicals on Growth & Development in Organisms

    Plants and animals need elements, such as nitrogen, phosphorus, potassium, and magnesium for proper growth and developme..

    Freshwater lake ecosystem
    Freshwater Producers and Consumers

    Freshwater ecosystem is comprised of four major constituents, namely elements and compounds, plants, consumers, and deco..

    Genetics – Lesson Outline & Worksheets
    Genetics – Lesson Outline & Worksheets

      Topics Modules Quizzes/Worksheets Description Introduction to Genetics Genetics – Definition: Heredity and ..