A transfection method that makes use of magnetic fields in order to deliver nucleic acid into the recipient cell
Magnetofection is a combination of the words magnet and transfection. Transfection is a process by which genetic material may be introduced into the target cell in order to reach the nucleus and be expressed. The term magnet is used to describe the process of transfection since it makes use of magnetic fields to enable it. Transfection can be done in various ways. It can be mediated using specific chemicals such as calcium phosphate, cationic liposomes, and dendrimers. It can also be through physical means such as magnetofection.
Magnetofection is a method that attempts to improve the efficiency of delivery methods. It also prevents toxicity, which is the disadvantage of chemical-based transfection methods.
In magnetofection, the nucleic acids need to be associated first with magnetic nanoparticles so that when magnetic force is applied the nucleic acid complex will be driven into the target cell.1
Magnetofection can be used to deliver all types of nucleic acids, such as DNA, siRNA, dsRNA, shRNA, mRNA, and so on.
- magnet-assisted transfection
1“Magnetofection — Magnetic assisted transfection & transduction”. OzBiosciences The art of delivery systems.