One of the forms nutritional anaemia which is characterized by the formation of larger than normal cells of the erythropoietic process. The cells are characterized based on the cell size which is larger than normal cell size( RBC size).
megaloblastic anaemia can be divided into folate deficiency and Vit.B12 deficiency anaemia. Deficiencies of either of these vitamins produce a general index with such features like anorexia, weight loss, poor memory, weakness and malaise. In this kind of anaemia, cells that are actively growing and dividing are particularly liable to be affected.
causes of megaloblastic anaemia:
- Alcohol intake
- Imbalanced diet, etc.
- Folate deficiency – folate exists naturally in daily food intake while the synthetic type of this vitamin is the folic acid. They are both vitamins that are required for the production of blood cells and normal dna and rna production.
- chronic liver diseases
- decreased production of intrinsic factor (this disease entity is called pernicious anemia)
- intestinal malabsorption (due to an enteritis, celiac disease or other causes)
- fish tapeworm infestation (diphyllobothrium latum)
- failure to replicate chromosomes due to lack of thymidine.
- Lesch-Nyhan syndrome