The complete set of metabolites within a cell, a tissue, or an organism under a particular condition
A metabolome refers to all the metabolites found within a cell or a biological sample under a particular condition. The biological sample may also be a tissue, an organ, or an organism.
The metabolome includes endogenous substances, such as organic acids, nucleic acids, amino acids, carbohydrates, fatty acids, amines, vitamins, co-factors, pigments, and so on. It may also include exogenous substances, such as drugs, food additives, toxins, and food additives as long as they are produced biologically. Biological constituents of the metabolome have a molecular weight of less than 1500 Da.1
Similar to metabolites, the metabolome may be grouped into primary and secondary. The primary metabolome is a set of substances crucial to growth, development, and reproduction. The secondary metabolome is the group of substances that are not directly involved in growth, development, and reproduction but essential for its ecological function. Examples of biological substances included in the secondary metabolome are antibiotics, pigments, and byproducts of partially metabolized xenobiotics.1
Metabolomics is the study of metabolome. An online database describing a variety of metabolites (>40,000) in the human body can be accessed freely via the Human Metabolome Database.
1 Metabolome. (n.d.). Wikipedia.org. Retrieved from https://en.wikipedia.org/wiki/Metabolome