An isozyme of flavin monoamine oxidase family that degrades neurotransmitters such as dopamine, serotonin and norepinephrine localizes at the outer mitochondrial membrane.
Monoamine oxidase A is a member of flavin monoamine family that is mapped on chromosome Xp11.3 where in human has 30-base repeat sequence in several numbers of times at the promoter region of the gene such as 2R, 3R, 3.5R, 4R, and 5R variants of the repeat sequence.
Monoamine oxidase A deficiency is characterized mostly in low levels of monoamine oxidase activity which has been implicated with increase behavioral problems such as violence and impulsiveness. Low amount of monoamine oxidase A activity to the abused children during childhood results in an increased risk of aggressive behavior as an adult. High testosterone, maternal tobacco smoking during pregnancy, poor material living standards can also trigger violent behavior with low activity in alleles. It is also related to depression disorder which is link with high variants to major depression in females, suicidal tendency in males and depressive disorder in both males and females.
Mutation of monoamine oxidase A gene caused in Brunner syndrome and has been commonly referred as the warrior gene wherein allele associated with behavioral traits shorter than 30-base repeats resulted in low amount may produce of monoamine oxidase enzyme.
Gene name: MAOA
Protein name: Amine oxidase flavin-containing A
• Monoamine oxidase type A
• Valproic Acid
• Amine oxidase