A protein responsible for the transport of pyruvate, lactic acids and ketone bodies involved in metabolic requirements of the tissues.
Monocarboxylate transporter 5 genes mapped on chromosome 1p13.3 containing 9 exons with multiple alternative transcript variant isoforms that act as proton-linked monocarboxylate transporter localized in the cell membrane as carbohydrate transport and metabolism. Lactic acid is the end product during normal glycolysis and transported out of the cells to keep up high rate of glycolysis on the other hand failure to export this lactic acid resulted in the increase of pH, inhibition of glycolysis and building-up of lactic acid in tissues.
Monocarboxylate transporter 5 catalyzed various transport of monocarboxylate across plasma membrane like pyruvate lactate, amino acid from leucine, isoleucine, valine, ketone and acetate which is important in tissues including red blood cells and skeletal muscle that uses this pathway to generates ATP under normal physiological conditions.
Monocarboxylate transporter 5 gene mutations implicated in some disease like ischemia and suitable candidate for sodium-linked transporter since its expression is mostly high in kidney.
Gene name: SLC16A4
Protein name: Monocarboxylate transporter 5
• Monocarboxylate transporter 4
• Solute carrier family 16 member 4