A form of hepatitis that affects the fetuses and neonates, and characterized by jaundice, direct and indirect bilirubinaemia, hepatocellular degeneration, and appearance of multinucleated giant cells in the liver
The hepatitis is a condition characterized by the inflammation of the liver. The common symptoms include jaundice (yellow discoloration of the skin and the whites of the eyes) and hepatomegaly (liver enlargement). There are many reasons that can result in hepatitis. The various causes include infection, metabolic factors, autoimmune causes, and genetic factors. One of these is neonatal hepatitis. It is hepatitis in the neonatal period presumed to be due to a variety of causes, chiefly viral. Possible viral causes include infection from hepatitis A virus, hepatitis B virus, hepatitis C virus, toxoplasma, rubella, cytomegalovirus, and syphilis.1 It is characterized by direct and indirect bilirubinaemia, hepatocellular degeneration, and appearance of multinucleated giant cells. Thus, it is also referred to as giant cell hepatitis. It may be difficult to distinguish from biliary atresia. Nevertheless, it is more likely to end with recovery although cirrhosis may develop.
- giant cell hepatitis
1 Samyn, M. and Mieli-Vergani, G. (November 2015). “Liver and Biliary Disease in Infancy”. Medicine. 43 (11): 625–630.