Dictionary > Neuropilin 1

Neuropilin 1

Neuropilin 1 is a membrane-bound isoform that binds to various ligands and co-receptors, necessary for cell adhesion, migration, and survival. In humans, the receptor is encoded by NRP1 gene that is mapped on chromosome 10. The gene encodes two neuropilins that contain specific protein domains that participate in various signaling pathways controlling cell migration. It has an N-terminal extracellular domain finished from complement-binding coagulation factor V and meprins that also contain small spanning and small cytoplasmic domain. As a receptor, it is involved in axon guidance expressed in dendritic cell and resting T cells. Thus, it mediates the interactions of dendritic cells and T cells that are significant for the initiation of the primary immune responses. It also plays a versatile role in angiogenesis, cell survival, axon guidance, invasion, and migration. Soluble neuropilin 1 interacts in hemophilic manner on both dendritic and T cells. Neuropilin 1 mediates an interaction with the essential element in the initiation of the primary immune response like agrin molecule necessary for neurologic and immunologic synapses. It is also involved in the development of the cardiovascular system, the formation of the neuronal circuits and organogenesis outside the nervous system. Abbreviation: NRP. Synonyms: vascular endothelial cell growth factor 165 receptor, CD304, VEGF165R, NP1, BDCA4.

See also

© Biology Online. Content provided and moderated by Biology Online Editors

You will also like...

Disturbance on a still water
Abiotic Factors – Water Conditions

A still body of water may be disturbed by a variety of factors. One of them is wind. In fact, it is considered as the pr..

Buttress roots

This study guide tackles plant roots in greater detail. It delves into the development of plant roots, the root structur..

IQ, Creativity and Learning
IQ, Creativity and Learning

Human intelligence provided the means to utilize abstract ideas and implement reasoning. This tutorial takes a further l..

Crossing Over and Genetic Diversity
Inheritance and Probability

Gregor Mendel, an Austrian monk, is most famous in this field for his study of the phenotype of pea plants, including ..

Population Growth and Survivorship
Population Growth and Survivorship

This lesson looks at population attributes, regulation, and growth. It also covers population genetics, particularly gen..

3D rendering of an antibody
Passive and Active Types of Immunity

Lymphocytes are a type of white blood cell capable of producing a specific immune response to unique antigens. In thi..