Dictionary > Pdgf

Pdgf

PDGF –>
platelet-derived growth factor
(Science: growth factor) The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing.
It is carried in the alphagranules of platelets and is released when platelets adhere to traumatised tissues. Connective tissue cells near the traumatised region respond by initiating the process of replication.
The b chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for platelet derived growth factor, suggesting that transformation is caused by autocrine stimulation. The receptor is a tyrosine kinase.
Acronym: PDGF


You will also like...

Buttress roots
Roots

This study guide tackles plant roots in greater detail. It delves into the development of plant roots, the root structur..

primitive arthropods
Arthropods

The arthropods were assumed to be the first taxon of species to possess jointed limbs and exoskeleton, exhibit more adva..

Angle Oak Tree
Seed Plants

Seed plants are vascular plants. They differ from the other vascular plants in producing seeds that germinate into a new..

Birth of a Human Baby
Birth of a Human Baby

Following nine months inside the mother's womb is the birth of the baby. Know the different stages of the birthing proce..

Biological Viruses
Biological Viruses

Viruses possess both living and non-living characteristics. This unique feature distinguishes them from other organisms...

Neurology of Illusions
Neurology of Illusions

Illusions are the perceptions and sensory data obtained from situations in which human error prevents us from seeing the..