PDGF –>
platelet-derived growth factor
(Science: growth factor) The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing.
It is carried in the alpha-granules of platelets and is released when platelets adhere to traumatised tissues. Connective tissue cells near the traumatised region respond by initiating the process of replication.
The b chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for platelet derived growth factor, suggesting that transformation is caused by autocrine stimulation. The receptor is a tyrosine kinase.
Acronym: PDGF
Dictionary > Pdgf
You will also like...

New Zealand’s Unique Geographical History
Explore why New Zealand has such unique flora and fauna, and learn why long periods of geographical isolation. This less..

Cell Respiration
Cell respiration is the process of creating ATP. It is "respiration" because it utilizes oxygen. Know the different stag..

Gibberellins and Gibberellic Acid
This tutorial describes the role of gibberellin family in plants. Find out the effects of gibberellin on plant growth an..

Genetics – Lesson Outline & Worksheets
Topics Modules Quizzes/Worksheets Description Introduction to Genetics Genetics – Definition: Heredity and ..

Genetic Mutations
This tutorial looks at the mutation at the gene level and the harm it may bring. Learn about single nucleotide polymorph..

Freshwater Lentic Communities & Animals
This tutorial looks at some of the communities in freshwater lentic habitats. For instance, symbiosis occurs in a commun..