Promyelocytic leukaemia (PML) protein is a protein encoded by the PML gene. In humans, the gene is located on the q arm of chromosome 15. There are about 15 PML protein isoforms identified. They all have a TRIpartite motif made up of a zinc RING finger, two zinc-binding domains, and RBCC dimerization domain.(1) They vary though at the c-terminal domain. PML proteins after translation at the ribosomal site in the cytoplasm are imported to the nucleus where they interact with each other at the RBCC domain. They are a major component of the PML body, which, in turn, is a type of nuclear body in the nuclear matrix of a mammalian cell involved in genome stability and apoptosis.
- Pearson, M. & Pelicci, P. G. (2001). “PML interaction with p53 and its role in apoptosis and replicative senescence”. Oncogene. 20 (49): 7250–6.
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