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Shone’s syndrome

Shone’s syndrome is a congenital heart disease first described by English cardiologist, John Shone. It is a rare disease that mostly affects children. By the age of two, the condition presents itself by the following symptoms: fatigue, nocturnal cough, and reduced cardiac output. The complete form is comprised of the following defects: supravalvular mitral membrane defect, sub-aortic stenosis, parachute mitral valve, and narrowing of the aortic valve. These defects affect the left side of the heart, causing an obstruction to the blood flow in the left ventricle. Synonyms: Shone’s anomaly, Shone’s complex, Shone’s disorder, Shone’s anomaly.


  1. Shone, J. D., Sellers, R. D., Anderson, R. C., Adams, P., Lillehei, C. W., & Edwards, J. E. (1963). “The Developmental Complex of “Parachute Mitral Valve,” Supravalvular Ring of Left Atrium, Subaortic Stenosis and Coarctation of Aorta”. Am J Cardiol. 11 (6): 714–25.

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