Specific granule refers to any of the secretory vesicles in the granulocytes. It is one of the two major types of granules in granulocytes. The other is the azurophil granule. The specific granules are released more readily than the azurophil granules. They are released by granulocytes (i.e. polymorphonuclear leukocytes and mast cells) through degranulation process in response to an immune stimulus. The presence of specific granules and the azurophil distinguishes the granulocytes from another type of leukocytes, the agranulocytes, which seem to lack both of these cytoplasmic granules under the light microscope. Granulocytes store specific granules as a mixture of cytotoxic substances. Neutrophils typically contain lactoferrin, lysozyme, NADPH oxidase, and alkaline phosphatase. Basophils have heparin (as well as histamine). Eosinophils have cathepsin. Synonym: secondary granule.
- Greer, J. P. & Wintrobe, M. M. (1 December 2008). Wintrobe’s clinical hematology. Lippincott Williams & Wilkins. pp. 173–. https://books.google.com.ph/books?id=68enzUD7BVgC&pg=PA173&redir-esc=y#v=onepage&q&f=false
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