Spite

spite
1. Ill-will or hatred toward another, accompanied with the disposition to irritate, annoy, or thwart; petty malice; grudge; rancor; despite. This is the deadly spite that angers. (Shak)
2. Vexation; chargrin; mortification. In spite of, or Spite of, in opposition to all efforts of; in defiance or contempt of; notwithstanding. Continuing, spite of pain, to use a knee after it had been slightly ibnjured. . And saved me in spite of the world, the devil, and myself. . In spite of all applications, the patient grew worse every day. . See Syn. Under Notwithstanding. To owe one a spite, to entertain a mean hatred for him.
Synonym: pique, rancor, malevolence, grudge.
Spite, malice. Malice has more reference to the disposition, and spite to the manifestation of it in words and actions. It is, therefore, meaner than malice, thought not always more criminal. Malice . . . Is more frequently employed to express the dispositions of inferior minds to execute every purpose of mischief within the more limited circle of their abilities. . Consider eke, that spite availeth naught. . See pique.
Origin: Abbreviated fr. Despite.