Stress granule refers to any of the cytosolic granules (100 – 200 nm) composed of proteins and mRNAs that form when the cell is under stress, e.g. exposure to heat or cold, oxidative stress, hyperosmotic stress, or UV. The formation of stress granules during cellular stress is presumed to be associated with protecting the RNAs from such conditions. Stress granules are closely associated with the stress response of endoplasmic reticulum. Possible pathways of stress granules are for storage, for degradation, or for re-initiation of translation. In some references, stress granules are regarded as non-membrane-bound organelles just as ribosomes, spliceosomes, centrioles, and cytoskeleton. In other references though, they are not organelles but cytoplasmic structures for their lack of a biological membrane.
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