A protein that is a member of inhibitor apoptosis family that has the capacity to hold back caspase activation which is important to programmed cell death and key regulator of the mitosis.
Survivin also known as baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) which contains 4 exons in survivin gene and mapped to chromosomes 17q25. It is vastly expressed in human cancers associated with chemotherapy struggle and augmented tumor recurrence, production of anti-survivin therapy is a striking cancer treatment strategy. It is also found in fetal tissue but totally absent in terminally differentiated cells.
Survivin portrays to inhibit caspase-9 though in recent findings it shows the role in cancer pathogenesis not only limited to apoptosis inhibition but also engaged in regulation of mitotic spindle checkpoint and endorsement of angiogenesis and chemo-resistance. The gene expression is transcriptionally repressed by wild type p53 that can be deregulated in cancer through hypomethylation, gene amplification and increased promoter activity.
Survivin also expressed in adult normal cells such as the primitive hematopoietic cells, vascular endothelial cells, T lymphocytes and polymorphonuclear neutrophils that regulate proliferation for survival which proposed that survivin might offer a new target for cancer therapy that would distinguish between transformed and normal cells.
Gene name: BIRC5
Protein name: Baculoviral IAP repeat-containing protein 5
• Apoptosis inhibitor survivin
• Apoptosis inhibitor 4
• survivin variant 3 alpha
• caspase inhibitor