A syndecan proteoglycan members involved in diverse role of cell binding, cell signaling, cytoskeletal organization and cell communication by helping as co-receptors in extracellular matrix molecules.
Syndecan-2 gene is mapped on chromosome 8q22-q24 with a molecular weight of 22,160 Da that mostly expressed in cells of mesenchymal origin presents as homodimers or multimers expressed in developmental and cell type specific patterns. It is structurally diverse side chains considerably to the size of the core protein that serves as binding sites for growth factors, cytokines and extracellular matrix proteins.
Syndecan-2 functions as a fundamental membrane protein that participates in cell proliferation, cell migration and cell matrix exchanges through its receptor for extracellular matrix proteins. It also mediates cell adhesion and proliferation of colon carcinoma cells.
Syndecan-2 mutations has been implicated in several tumor types in the formation of particular membrane domains and functions as a direct linked involving extracellular environment and association of the cortical cytoplasm. It is needed for angiogenesis by serving as co-receptors for endothelial growth factor and cell signaling throughout the development of asymmetry thereby serves as a potential drug target for the development of multifunctional anticancer therapeutics.
Gene name: SDC2
Protein name: Syndecan-2
• Heparan sulfate proteoglycan core protein