noun, plural: thromboxanes B2
One of the major eicosanoids, with a chemical formula of C20H34O6, and important in the platelet-release reaction, particularly in the release of ADP and serotonin; thromboxa-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,13E,15S)-
Eicosanoid is the generic term to refer to the compounds derived from arachidonic acid or other polyunsaturated fatty acids of 20-carbon length. Thromboxanes are one of the groups of eicosanoids. Thromboxanes are produced biosynthetically by activated platelets. Within the cell, prostaglandin cyclic endoperoxides, e.g. prostaglandin H2, are converted into thromboxanes through the aid of the enzymes, thromboxane synthases. The thromboxanes are characterized by having a six-membered ether-containing ring and their role in thrombosis. Two of the major thromboxanes are thromboxane A2 (TxA2) and thromboxane B2 (TxB2).
Thromboxane B2 is a stable, physiologically active compound that occurs naturally. It is formed in vivo from the prostaglandin endoperoxides.
Thromboxane B2 is important in the platelet-release reaction, particularly, in the release of ADP and serotonin. It is a more stable compound than TxA2. Nonetheless, it is the inactive metabolite of TxA2. Unlike TxA2, TxB2 is not directly involved in platelet activation and aggregation during wound healing.