Dictionary > Thyrotropin-releasing hormone

Thyrotropin-releasing hormone

noun, plural: thyrotropin-releasing hormones
A releasing hormone (chemical formula: C16H22N6O4) produced by the hypothalamus, and acts by stimulating the release of thyroid-stimulating hormone and prolactin from the anterior pituitary
Thyrotropin-releasing hormone is one of the various hormones produced by the hypothalamus. It is a releasing hormone, influencing the anterior pituitary to release thyroid-stimulating hormone (TSH) and prolactin.
Thyrotropin-releasing hormone is a tripeptide hormone: (pyro)Glu-His-Pro-NH2. It is synthesized by the parvocellular neurosecretory neurons of the paraventricular nucleus of the hypothalamus. It is then moved across the median eminence to the anterior pituitary via the hypophyseal portal system. The target cell of the thyrotropin-releasing hormone is the thyrotroph. The thyrotrophs are the cells in the anterior pituitary that release TSH. These cells release TSH in response to thyrotropin-releasing hormone from the hypothalamus. TSH is a glycoprotein hormone that works by stimulating the thyroid to produce and release thyroid hormones, particularly thyroxine. One of the functions of thyroxine is to serve as a precursor of triiodothyronine, the active form of thyroid hormone.
Thyrotropin-releasing hormone is used clinically. It is used for treating spinocerebellar degeneration. It has been found to have anti-depressant and anti-suicidal effects.
Chemical formula:

  • C16H22N6O4


  • TRH
  • Synonym(s):

    • thyrotropin-releasing factor (TRF)
    • thyroliberin

    See also:

  • thyroid-stimulating hormone
  • releasing hormone
  • prolactin
  • anterior pituitary
  • Related term(s):

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