Dictionary > Tyrosine hydroxylase

Tyrosine hydroxylase

An enzyme that is involved in catecholamine synthesis mediating the neuron oxidative state for the physiology associated in nervous system.
Tyrosine hydroxylase gene is mapped on chromosome 11p15 that plays important functions in the conversion of amino acid L-tyrosine to L-DOPA using molecular oxygen and iron as co-factors. It is an enzyme present in the central nervous system, peripheral symphatic neurons and adrenal medulla.
Tyrosine hydroxylase gene mutations lead to deficiency since this enzyme provides instruction that is important for normal functioning of the nervous system taking part in the pathway that generates chemical hormones which helps to convert amino acid tyrosine to catecholamine that eventually formed dopamine, a protein that transmit signals to help the brain controls physical movement and emotional behavior. Moreover this catecholamine also assists in norepinephrine and epinephrine produced from dopamine involved in the autonomic nervous system thus, less production of dopamine, norepinephrine and epinephrine contributes to the abnormal movements, autonomic dysfunction and neurological problems.
Tyrosine hydroxylase deficiency usually appears during childhood showing disorder in movement wherein individual exhibit abnormal limb positioning and lack of coordination in walking or running. It is also associated in movement problems like shaking when griping objects and involuntary upward rolling movements of the eyes. The harsh form of tyrosine hydroxylase deficiency linked with infantile Parkinson’s disease and encephalopathy which appears soon after birth and more difficult to treat hence, these conditions inherited in an autosomal recessive pattern in which both copies of genes in each cell undergo mutations.
Gene name: TH
Protein name: Tyrosine 3-monooxygenase
• Tyrosine 3-hydroxylase
See also:

You will also like...

Balanced Diet
A Balanced Diet – Minerals and Proteins

Proteins and minerals can be derived from various dietary sources. They are essential for the proper growth and developm..

Early Earth
The Origins of Life

This tutorial digs into the past to investigate the origins of life. The section is split into geological periods in the..

Cells in different stages of meiosis
Meiosis – The Genetics of Reproduction

Meiosis is a form of cell division that creates gametes. It is comprised of two divisions that in the end, the resulting..

An artistic depiction of a human embryo
Growth and Development of a Human Baby

Upon fertilization, a zygote forms and develops into an embryo. This tutorial elaborates on the growth and development f..

An artist's depiction of the origin of amphibians
Amphibians & Early Reptiles

Obtaining air outside an aquatic environment required species to acquire suitable adaptations, and this was the case of ..

Human perception in action
Human Perception – Neurology

This tutorial investigates perception as two people can interpret the same thing differently. Know more about human perc..