A nuclear hormone receptor implicated as ligand inducible transcription factors that is essential in regulating the levels of calcium and phosphate in the body.
Vitamin D Receptor gene is mapped on chromosome 12q12-q14 which binds the hormones with high affinity and regulates the expression of genes via zinc finger mediated DNA binding and protein-protein interactions. It expresses TRL2 receptor express on the surface of the cell that distinguishes foreign substances.
Vitamin D Receptor is located in the nucleus of a variety of cells including immune cells where it acts as a control system when cells exposed to infection or damage especially those that cause by pathogens. It transcribes hundreds of genes including those proteins known as antimicrobial peptides, the body’s natural antibiotics for the prevention and clearance of infection.
Vitamin D Receptor significantly affects 229 genes that have been long associated with autoimmune disease and cancers as well as multiple sclerosis and Crohn’s disease. It controls innate immune response, a first line of defense in the body against bacterial pathogens.
Gene name: VDR
Protein name: Vitamin D3 receptor
• 1,25-dihydroxyvitamin D3 receptor
• Nuclear receptor subfamily 1 group I member 1
• Vitamin D Hormone Receptor
• Nuclear hormones