Articles > Phosphodiester bond definition – quiz Phosphodiester bond definition – quiz Quiz Choose the best answer. 1. Which is NOT true about phosphodiester bond? An ester bond Forms between phosphate groups and hydroxyl groups of two sugar groups Results from hydrolysis reaction 2. Phosphodiester bond is a type of ... Covalent bond Ionic bond Hydrogen bond 3. The enzyme that can break a phosphodiester bond Phosphodiesterase Phosphatase Phosphorylase 4. Which of the following contains a phosphodiester bond RNA DNA Either RNA or DNA 5. Which of the following is a function of a phosphodiester bond? Holds cation and anion together Connects water molecules together Responsible for the structural backbone of the nucleic acids Send Your Results (Optional) Your Name To Email Time is Up!