Dictionary > Autophosphorylation

Autophosphorylation

Definition
noun
(biochemistry) The phosphorylation of the kinase through its own enzymatic activity
Supplement
Autophosphorylation is a biochemical process in which a phosphate is added to a protein kinase by itself. In eukaryotes, autophosphorylation takes place by the addition of a phosphate group to serine, threonine, or tyrosine residues in protein kinases.1, 2 Most of the phosphate groups added are from nucleoside triphosphates such as ATP.1 The name is due to the phosphorylation reaction that takes place through its own enzymatic activity. This process is essential in cell signaling. It causes a conformational change to expose or hide catalytic or allosteric sites, thereby regulating kinase activity (e.g. substrate binding or molecular recognition).1 Apart from this, autophosphorylation is also reported to be involved in enabling cells for endocytosis and proteolysis.3
See also:

Mentioned in:

  • Receptors insulin
  • Focal Adhesion Kinase
  • Receptors macrophage colony-stimulating factor
  • Mortalin
  • Reference(s):

    1Petsko, GA and Ringe, D 2009, ‘Protein Structure and Function’, Oxford University Press Inc., New York, U.S.A

    2 Summers, K. C.; Shen, F.; Sierra Potchanant, E. A.; Phipps, E. A.; Hickey, R. J.; Malkas, L. H. (2011). “Phosphorylation: The Molecular Switch of Double-Strand Break Repair”. International Journal of Proteomics 2011: 1.

    3 Smith, J. A.; Francis, S. H.; Corbin, J. D. (1993). “Autophosphorylation: A salient feature of protein kinases”. Molecular and cellular biochemistry. 127-128: 51–70.


    You will also like...

    Human Reproduction
    Human Reproduction

    Humans are capable of only one mode of reproduction, i.e. sexual reproduction. Haploid sex cells (gametes) are produced ..

    Origins of Life on Earth
    Origins of Life on Earth

    Earth was created around 4.5 billion years ago and life began not long after. Primitive life likely possessed the elemen..

    squirrel
    Animal Water Regulation

    Animals adapt to their environment in aspects of anatomy, physiology, and behavior. This tutorial will help you understa..

    New Zealand Fauna
    New Zealand’s Unique Fauna

    Meet some of New Zealand's unique fauna, including endemic insects, frogs, reptiles, birds, and mammals, and investigate..

    Muscle
    Muscle

    Muscle cells are specialized to generate force and movement. Learn about the different types of muscle tissues in this t..

    Crossing Over and Genetic Diversity
    Inheritance and Probability

    Gregor Mendel, an Austrian monk, is most famous in this field for his study of the phenotype of pea plants, including ..

    Related Articles...

    No related articles found

    See all Related Topics