Dictionary > Autophosphorylation

Autophosphorylation

Definition
noun
(biochemistry) The phosphorylation of the kinase through its own enzymatic activity
Supplement
Autophosphorylation is a biochemical process in which a phosphate is added to a protein kinase by itself. In eukaryotes, autophosphorylation takes place by the addition of a phosphate group to serine, threonine, or tyrosine residues in protein kinases.1, 2 Most of the phosphate groups added are from nucleoside triphosphates such as ATP.1 The name is due to the phosphorylation reaction that takes place through its own enzymatic activity. This process is essential in cell signaling. It causes a conformational change to expose or hide catalytic or allosteric sites, thereby regulating kinase activity (e.g. substrate binding or molecular recognition).1 Apart from this, autophosphorylation is also reported to be involved in enabling cells for endocytosis and proteolysis.3
See also:

Mentioned in:

  • Receptors insulin
  • Focal Adhesion Kinase
  • Receptors macrophage colony-stimulating factor
  • Mortalin
  • Reference(s):

    1Petsko, GA and Ringe, D 2009, ‘Protein Structure and Function’, Oxford University Press Inc., New York, U.S.A

    2 Summers, K. C.; Shen, F.; Sierra Potchanant, E. A.; Phipps, E. A.; Hickey, R. J.; Malkas, L. H. (2011). “Phosphorylation: The Molecular Switch of Double-Strand Break Repair”. International Journal of Proteomics 2011: 1.

    3 Smith, J. A.; Francis, S. H.; Corbin, J. D. (1993). “Autophosphorylation: A salient feature of protein kinases”. Molecular and cellular biochemistry. 127-128: 51–70.


    You will also like...

    Chemical composition of the body
    Chemical Composition of the Body

    The body is comprised of different elements with hydrogen, oxygen, carbon, and nitrogen as the major four. This tutorial..

    Ploidy
    Polyploidy

    Humans are diploid creatures. This means that for every chromosome in the body, there is another one to match it. Howeve..

    Plant Water Regulation
    Plant Water Regulation

    Plants need to regulate water in order to stay upright and structurally stable. Find out the different evolutionary adap..

    Thermographic image of face and neck
    Regulation of Organic Metabolism, Growth and Energy Balance

    The human body is capable of regulating growth and energy balance through various feedback mechanisms. Get to know the e..

    Still Water Animals
    Still Water Animals

    Animals living in aquatic habitats have diversified and evolved through time. They eventually occupy ecological niches a..

    "Cronopio dentiacutus", a prehistoric mammal (an illustration)
    Mammalian Ancestors

    Mammals are a diverse group of organisms, where most of them develop their offspring within the uterus of the mother. Ov..