Gout
(Science: rheumatology) recurrent acute arthritis of peripheral joints caused by the accumulation of monosodium urate crytals. Often presents as pain and swelling confined to one joint. The big toe joint is commonly affected.
The arthritis occurs secondary to an inherited Abnormality of purine metabolism, resulting in the deposition of uric acid crystals (sodium urate) within the joint space and articular cartilage.
Usually due to overproduction of uric acid but may be a result of under excretion. The problems partly arise because neutrophils release lysosomal enzymes as a result of damage to the phagosome membrane by ingested crystals: colchicine acts to reduce the attack by inhibiting lysosome phagosome fusion.
Dictionary > Gout
You will also like...

The Homo Species
The evolution of the species of the genus "Homo" led to the emergence of modern humans. Find out more about human evolut..

Chromosomes X and Y and Sex Determination
This tutorial looks at sex determination via the sex chromosomes, X and Y. Read it to get more info on X and Y chromosom..

Neural Control Mechanisms
Neurons generate electric signals that they pass along to the other neurons or target tissues. In this tutorial, you wil..

Freshwater Communities & Lentic Waters
Lentic or still water communities can vary greatly in appearance -- from a small temporary puddle to a large lake. The s..

Freshwater Producers and Consumers
Freshwater ecosystem is comprised of four major constituents, namely elements and compounds, plants, consumers, and deco..

Growth and Development of a Human Baby
Upon fertilization, a zygote forms and develops into an embryo. This tutorial elaborates on the growth and development f..