Dictionary > Hemoglobinopathy

Hemoglobinopathy

Definition
noun, plural: hemoglobinopathies
A genetic disorder resulting in an abnormal globin structure in the hemoglobin molecule
Supplement
Hemoglobin is a biomolecule found in the red blood cells of vertebrates. It is made up of heme and globin portions. The heme portion of the hemoglobin is one that binds to the oxygen molecules. There are four types of globin polypeptide chains in adult hemoglobin and they are designated as alpha, beta, gamma, and delta. Hemoglobinopathy is a genetic disorder resulting in the alteration of one globin chain in the hemoglobin molecule.1 Genetic alterations occur when one or more amino acids in the globin portion of the molecule are substituted at certain positions in the alpha or beta polypeptide chains.2 Most of the hemoglobinopathies are autosomal co-dominant traits.3 An example of hemoglobinopathy is sickle cell anemia, which is a genetic disorder due to the abnormality in the hemoglobin molecule. Another is hemolytic anemia caused by a defect in the hemoglobin production.
Variant(s):

  • haemoglobinopathy

See also:

  • hemoglobin
  • hemoglobinuria
  • Reference(s):

    1 hemoglobinopathy. (n.d.) Dorland’s Medical Dictionary for Health Consumers. (2007). Retrieved from Link

    2 hemoglobinopathy. (n.d.) Mosby’s Medical Dictionary, 8th edition. (2009). Retrieved July 18 2015 from Link

    3 Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704-712.


    You will also like...

    Mātauranga Māori and Science Collaboration
    Mātauranga Māori and Science

    Mātauranga Māori is the living knowledge system of the indigenous people of New Zealand, including the relationships t..

    Direct and indirect physiologic effects of growth hormone
    Animal Growth Hormones

    Hormones are produced in the endocrine glands of animals. The pituitary gland and hypothalamus are the most impor..

    Peppered moth ("Biston betularia") melanic and light form
    Examples of Natural Selection

    Darwin's Finches are an example of natural selection in action. They are an excellent example of the way species' gene p..

    3D rendering of an antibody
    Passive and Active Types of Immunity

    Lymphocytes are a type of white blood cell capable of producing a specific immune response to unique antigens. In thi..

    Still Water Animals
    Still Water Animals

    Animals living in aquatic habitats have diversified and evolved through time. They eventually occupy ecological niches a..

    Schematic diagram of DNA replication
    DNA Structure & DNA Replication

    DNA is a double helix structure comprised of nucleotides. A nucleotide, in turn, is made up of phosphate molecule, deoxy..

    Related Articles...

    No related articles found

    See all Related Topics