Dictionary > Koch postulate

Koch postulate

The four principles intended to ascertain the underlying relationships between a microbe and a disease.
It was established and formulated by Robert Koch and Friedrich Loeffler in 1884 based from the concepts illustrated by Jakob Henle.
The following are the four fundamental principles:
• The microbes must be in abundant and present in organisms suffering from disease.
• The microbes must be isolated and grown in a pure culture
• The pure culture must cause the disease when introduced into a healthy organism
• The microbes must be reisolated from the induce organism and being grown again in a culture media that shows similarity to the original pure culture.
Koch’s postulate has been useful in the etiology of tuberculosis and cholera yet, it has some limitations when the discoveries of asymptomatic or subclinical infections, thus abandoned the idea of the first postulate. However the second postulate might also suspended when some bacteria that cannot be grown in pure culture like the microbes responsible in leprosy and when there is no available animal model for that particular bacteria.
In spite of various limitations Koch’s postulates is still a constructive standard in evaluating whether there is a cause-and-effect relationship between a bacteria and a disease.
See also:
• Bradford Hill criteria
• Causal inference
• Mill’s Methods
• Molecular Koch’s postulates

You will also like...

Genetic Mutations
Chromosome Mutations – II

This tutorial is a continuation of the first lesson on chromosomal mutation. Here, find out the chromosomal aberrations ..

Biological Cell schematic diagram
Biological Cell Introduction

It only takes one biological cell to create an organism. A single cell is able to keep itself functional through its 'mi..

Neural Control Mechanisms
Neural Control Mechanisms

Neurons generate electric signals that they pass along to the other neurons or target tissues. In this tutorial, you wil..

Gibberellins and Gibberellic Acid
Gibberellins and Gibberellic Acid

This tutorial describes the role of gibberellin family in plants. Find out the effects of gibberellin on plant growth an..

Birth Control and Contraception
Birth Control and Contraception

Different pregnancy and birth control and contraception strategies are described. Read this tutorial to learn each of th..

Still Water Animals
Still Water Animals

Animals living in aquatic habitats have diversified and evolved through time. They eventually occupy ecological niches a..