Dictionary > Koch postulate

Koch postulate

Definition
noun
The four principles intended to ascertain the underlying relationships between a microbe and a disease.
Supplement
It was established and formulated by Robert Koch and Friedrich Loeffler in 1884 based from the concepts illustrated by Jakob Henle.
The following are the four fundamental principles:
• The microbes must be in abundant and present in organisms suffering from disease.
• The microbes must be isolated and grown in a pure culture
• The pure culture must cause the disease when introduced into a healthy organism
• The microbes must be reisolated from the induce organism and being grown again in a culture media that shows similarity to the original pure culture.
Koch’s postulate has been useful in the etiology of tuberculosis and cholera yet, it has some limitations when the discoveries of asymptomatic or subclinical infections, thus abandoned the idea of the first postulate. However the second postulate might also suspended when some bacteria that cannot be grown in pure culture like the microbes responsible in leprosy and when there is no available animal model for that particular bacteria.
In spite of various limitations Koch’s postulates is still a constructive standard in evaluating whether there is a cause-and-effect relationship between a bacteria and a disease.
See also:
• Bradford Hill criteria
• Causal inference
• Mill’s Methods
• Molecular Koch’s postulates


You will also like...

An artistic depiction of Dunkleosteus fish
Fish

The sea was teeming with life. Eventually, through reproduction and continued variation, fish came about. There are over..

An artist depiction of a Precambrian multicellular life form.
The Evolution of Cell Organelles

The nucleus containing the genetic material, DNA, and the mitochondria, well-identified as the "powerhouse of the cell",..

Structural depiction of catalase, an enzyme
Protein Activity and Cellular Metabolism

Proteins have a crucial role in various biological activities. Get to know how proteins are able to perform as enzymes, ..

Adaptive Radiation
Adaptive Radiation

The diversification of several new species from a recent ancestral source, each adapted to utilize or occupy a vacant ad..

Mātauranga Māori and Science Collaboration
Mātauranga Māori and Science

Mātauranga Māori is the living knowledge system of the indigenous people of New Zealand, including the relationships t..

Transpiration
Water in Plants

The movement of molecules (specifically, water and solutes) is vital to the understanding of plant processes. This tuto..