Dictionary > Langhans giant cell

Langhans giant cell

Definition
noun, plural: Langhans giant cells
A type of giant cell formed by the fusion of epithelioid macrophages, and characterized by nuclei that are arranged similar to a horseshoe and are located peripherally
Supplement
Langhans giant cells as the name implies are cells that are exceptionally large. They also have multiple nuclei. The nuclei of Langhans giant cell are located in the cell periphery. The nuclei are also arranged in a way that they resemble a horseshoe, which make them distinct from other giant cells such as Touton giant cells in which the nuclei are grouped forming a ring. Langhans giant cells derived their name after Theodor Langhans, a German pathologist.1
Langhans giant cells are formed similarly by the fusion of epitheliod cells (macrophages) just as the other types of giant cells. The fusion of these cells resulted in a large cell having multiple nuclei.
Langhans giant cells are often associated with tubercular lesions. They are also seen in certain types of granulomatous diseases. They are also related to syphilis, sarcoidosis and deep fungal infections.
Also called:

  • Pirogov-Langhans cell

See also:

  • giant cell
  • macrophage
  • Reference(s):

    1 Pritchard, J., Foley, P., & Wong, H. (September 2003). “Langerhans and Langhans: what’s misleading in a name?”. Lancet 362 (9387): 922.


    You will also like...

    river
    Running Water Freshwater Communities

    This tutorial introduces flowing water communities, which bring new and dithering factors into the equation for possible..

    Adaptation Tutorial
    Adaptation Tutorial

    Adaptation, in biology and ecology, refers to the process or trait through which organisms or the populations in a habit..

    Still Water Community Plants
    Still Water Community Plants

    This tutorial looks at the adaptations of freshwater plants for them to thrive in still water habitats. Familiarize your..

    A chart depicting Mendel's Law of Dominance
    Mendel’s Law & Mendelian Genetics

    One of Mendel’s law of inheritance is the “law of dominance”. Read this tutorial to know more about this form of i..

    Carbohydrates, fats and proteins - dietary sources
    A Balanced Diet – Carbohydrates and Fat

    Apart from vitamins, the human body also requires high energy sources such as carbohydrates and fats. If you want an ove..

    Homeostasis by water regulation
    Homeostasis of Organism Water Regulation

    Osmoregulation is the regulation of water concentrations in the bloodstream, effectively controlling the amount of water..