Dictionary > Langhans giant cell

Langhans giant cell

Definition
noun, plural: Langhans giant cells
A type of giant cell formed by the fusion of epithelioid macrophages, and characterized by nuclei that are arranged similar to a horseshoe and are located peripherally
Supplement
Langhans giant cells as the name implies are cells that are exceptionally large. They also have multiple nuclei. The nuclei of Langhans giant cell are located in the cell periphery. The nuclei are also arranged in a way that they resemble a horseshoe, which make them distinct from other giant cells such as Touton giant cells in which the nuclei are grouped forming a ring. Langhans giant cells derived their name after Theodor Langhans, a German pathologist.1
Langhans giant cells are formed similarly by the fusion of epitheliod cells (macrophages) just as the other types of giant cells. The fusion of these cells resulted in a large cell having multiple nuclei.
Langhans giant cells are often associated with tubercular lesions. They are also seen in certain types of granulomatous diseases. They are also related to syphilis, sarcoidosis and deep fungal infections.
Also called:

  • Pirogov-Langhans cell

See also:

  • giant cell
  • macrophage
  • Reference(s):

    1 Pritchard, J., Foley, P., & Wong, H. (September 2003). “Langerhans and Langhans: what’s misleading in a name?”. Lancet 362 (9387): 922.


    You will also like...

    Neural Control Mechanisms
    Neural Control Mechanisms

    Neurons generate electric signals that they pass along to the other neurons or target tissues. In this tutorial, you wil..

    Lentic community
    Freshwater Communities & Lentic Waters

    Lentic or still water communities can vary greatly in appearance -- from a small temporary puddle to a large lake. The s..

    Wart-like leaf galls on grape leaves
    Plant Cell Defense

    Plants protect themselves by releasing hydrogen peroxide to fight against fungal invasion. Another way is by secreting c..

    3D rendering of an antibody
    Passive and Active Types of Immunity

    Lymphocytes are a type of white blood cell capable of producing a specific immune response to unique antigens. In thi..

    Physical growth
    Physical Development in Humans

    This tutorial elaborates on the physical development of humans, particularly from puberty to adulthood. Read this tutori..

    Lake Wakatipu, New Zealand
    New Zealand’s Unique Geographical History

    Explore why New Zealand has such unique flora and fauna, and learn why long periods of geographical isolation. This less..

    Related Articles...

    No related articles found

    See all Related Topics