Dictionary > Mononuclear phagocyte system

Mononuclear phagocyte system

Definition
noun
A system of cells located in reticular connective tissue, and are associated primarily with phagocytosis and antigen processing and presentation
Supplement
The mononuclear phagocyte system is a system comprised of phagocytic cells located in reticular connective tissue. Reticular connective tissue is a type of connective tissue characterized by the predominance of reticular fibers, such as those found in spleen, lymph nodes, and bone marrow. The mononuclear phagocyte system is formerly referred to as reticuloendothelial system. The latter is no longer common for use since most endothelial cells are not macrophages.1
The mononuclear phagocytic system is part of the immune system. It consists of the phagocytic cells that are primarily involved in phagocytosis and antigen processing and presentation. Thus, the system is a part of both humoral and cell-mediated immunity. Apart from immune functions, the system is also involved in the formation of plasma proteins, new erythrocytes and leukocytes, and bile pigments, the storage of excess iron (e.g. as ferritin and as hemosiderin), the removal of old RBCs and WBCs by phagocytosis, and the clearance of heparin with the help of the enzyme heparinase.2
Examples of cells of mononuclear phagocyte system are as follows: 2 (1) adipose tissue macrophages in adipose tissues, (2) monocytes in bone marrow, (3) Kupffer cells in liver, (3) sinus histiocytes in lymph nodes, (4) alveolar macrophage in pulmonary alveolus of lungs, (5) histiocytes in connective tissues, (6) Langerhans cells in skin and mucosa, (7) microglia in central nervous system, (8) Hofbauer cells in placenta, (9) intraglomerular mesangial cells in kidneys, (10) osteoclasts in bone, (11) epithelioid cells in granulomas, (12) red pulp macrophages in the red pulp of spleen, and peritoneal macrophages in the peritoneal cavity.
Synonym(s):

  • reticuloendothelial system

See also:

  • immune system
  • macrophage
  • Reference(s):

    1 Singh, I. (2006). Textbook of Human Histology. Jaypee Brothers Publishers. pp. 90–.

    2 Mononuclear phagocyte system. Retrieved from https://en.wikipedia.org/wiki/Mononuclear-phagocyte-system.


    You will also like...

    Endemic Flora of New Zealand
    New Zealand’s Unique Flora

    If New Zealand has lots of unique animals, it's also got a whole lot of unique plants. Find out more about some of them,..

    Sensory systems
    Sensory Systems

    A sensory system is a part of the nervous system consisting of sensory receptors that receive stimuli from the internal ..

    Young plant growing from the soil.
    Soils

    Nutrients in the soil are essential to the proper growth of a land plant. This tutorial deals with the properties of soi..

    Ecological Research Measuring & Analysis
    Ecological Research: Measuring & Analysis

    This lesson is about the methods used for ecological research, such as quadrat and transect sampling, canopy fogging, an..

    Body temperature regulation by the hypothalamus
    Temperature Regulation in Animals

    This tutorial elucidates body temperature regulation. Know the details here to learn how the body sets the body temperat..

    kinesin motor proteins transporting molecules across microtubules
    Movement of Molecules Across Cell Membranes

    Molecules move within the cell or from one cell to another through different strategies. Transport may be in the form of..

    Related Articles...

    No related articles found

    See all Related Topics