Dictionary > O antigen

O antigen

Definition
noun
(microbiology) A repetitive glycan polymer attached to the core oligosaccharide of the LPS layer of certain bacteria; a somatic antigen that comprises the outermost domain of the lipopolysaccharide
(immunology) A major blood group antigen indicating the presence of H antigen and the lack of additional antigens, particularly N-Acetylgalactosamine (found in A antigen) and galactose (in B antigen)
Supplement
In microbiology, O antigen renders additional protection from the antimicrobial action of certain antibiotics. Without it, the LPS becomes hydrophobic and therefore is more susceptible to the action of hydrophobic antibiotics. 1
In immunology, blood types are determined by the presence of blood-group antigens. In humas, there are three types of blood-group antigens, namely H antigen, A antigen, and B antigen. They differ basically on structural component.
Synonym(s):

  • (microbiology) O polysaccharide
  • (microbiology) O side-chain

Compare:

  • (immunology) A antigen
  • (immunology) B antigen
  • See also:

    Reference(s):

  • 1Tsujimoto H et al. (2003). “Diffusion of macrolide antibiotics through the outer membrane of Moraxella catarrhalis”. Journal of Infection and Chemotherapy 74 (4): 1045–1055. doi:10.1007/s101569900025